Abstract
When injected unilaterally into the mouse striatum, cannabinoid agonists such as Win 55212-2 (1-100 ng/mouse), CP 55940 (0.1-50 ng/mouse), and anandamide (0.5-50 ng/mouse), the putative endogenous ligand of CB1 receptor, dose-dependently induced turning behavior. SR 141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H- pyrazole-3-carboxamide hydrochloride], the selective antagonist of CB1 receptor, antagonized the three cannabinoid receptor agonists-induced turning with similar ED50s (0.13-0.15 mg/kg, IP). Spiroperidol (a D2 receptor blocker), (+)-SCH 23390 (a D1 receptor blocker), or prior 6-OHDA lesions of the striatum blocked Win 55212-2- and CP 55940-induced turning, thus suggesting the involvement of DA transmission in cannabinoid-induced turning. Taken together, these findings reinforce the notion of a cannabinoid receptor-mediated control of nigrostriatal function.
MeSH terms
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Analgesics / pharmacology
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Animals
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Benzoxazines
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Cannabis / metabolism*
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Corpus Striatum / metabolism
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Corpus Striatum / physiology*
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Cyclohexanols / administration & dosage
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Cyclohexanols / pharmacology
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Dose-Response Relationship, Drug
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Female
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Injections
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Mice
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Morpholines / administration & dosage
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Morpholines / pharmacology
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Naphthalenes / administration & dosage
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Naphthalenes / pharmacology
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Neurons / drug effects
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Oxidopamine / toxicity
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Piperidines / administration & dosage
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Piperidines / pharmacology
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Pyrazoles / administration & dosage
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Pyrazoles / pharmacology
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Receptors, Cannabinoid
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Receptors, Drug / agonists*
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Receptors, Neurokinin-2 / antagonists & inhibitors
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Rimonabant
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Stereoisomerism
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Stereotyped Behavior / drug effects*
Substances
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Analgesics
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Benzoxazines
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Cyclohexanols
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Morpholines
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Naphthalenes
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Piperidines
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Pyrazoles
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Receptors, Cannabinoid
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Receptors, Drug
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Receptors, Neurokinin-2
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(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
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Oxidopamine
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Rimonabant