Abstract
Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / biosynthesis
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Bacterial Vaccines / immunology*
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Ganglia, Spinal / metabolism
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Mice
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Protein Binding
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Rats
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Recombinant Fusion Proteins
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Structure-Activity Relationship
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Tetanus Toxin / chemistry
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Tetanus Toxin / immunology*
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Tetanus Toxin / metabolism
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Vaccines, Synthetic / immunology*
Substances
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Bacterial Proteins
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Bacterial Vaccines
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Recombinant Fusion Proteins
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Tetanus Toxin
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Vaccines, Synthetic