Abstract
A 16 year-old boy with nephropathic cystinosis and kidney transplantation was successfully treated with rhGH because of growth retardation. After 15 months of rhGH therapy he developed impaired glucose tolerance. Various causes like cystinosis itself, the immunosuppressive therapy with cyclosporine A and cortisone, but rhGH too might have been the responsible factors for that. Treatment with rhGH was initiated again after 4 months of interruption of therapy because no relation between impaired glucose tolerance and GH could be established.
MeSH terms
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Adolescent
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Cystinosis / blood
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Cystinosis / surgery*
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Diabetes Mellitus, Type 1 / blood
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Diabetes Mellitus, Type 1 / diagnosis*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Follow-Up Studies
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Glucose Tolerance Test*
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Glycated Hemoglobin / metabolism
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Growth Hormone / administration & dosage
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Growth Hormone / adverse effects*
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Humans
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Injections, Subcutaneous
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Kidney Failure, Chronic / blood
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Kidney Failure, Chronic / surgery*
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Kidney Function Tests
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Kidney Transplantation / physiology*
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Male
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Postoperative Complications / blood
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Postoperative Complications / diagnosis*
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / adverse effects
Substances
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Glycated Hemoglobin A
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Recombinant Proteins
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Growth Hormone