Differential hemispheric involvement in controlling simple and complex motor movements was investigated in humans using EEG spectral responses. Analysis of spectral power in the alpha band revealed the following. While during a simple motor task (tapping) signs of unilateral cortical activation were present, more complex sequential motor behaviour (Luria finger apposition task) led to symmetrical bihemispheric activation. It appears that unilateral cortical processing is present in the normal brain when very simple computations are performed. Bilateral hemispheric activity and interhemispheric interaction may be general features of more complex information processing in the cortex.