Abstract
Nitric oxide production by mouse macrophages treated with group B streptococci and gamma interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-derived tumor necrosis factor alpha. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-treated macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Cytochalasin B / pharmacology
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Interferon-gamma / pharmacology*
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Macrophages / metabolism*
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Mice
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Mice, Inbred BALB C
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Nitric Oxide / physiology*
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Phagocytosis
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Recombinant Proteins
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Streptococcus agalactiae / physiology*
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Nitric Oxide
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Cytochalasin B
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Interferon-gamma