Abstract
We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing*
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Amino Acid Sequence
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Animals
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Base Sequence
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Biological Evolution
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Blotting, Northern
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Cloning, Molecular
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Conserved Sequence
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Cyclic AMP Response Element Modulator
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Cyclic AMP Response Element-Binding Protein / genetics*
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Cyclic AMP Response Element-Binding Protein / metabolism
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DNA-Binding Proteins / genetics
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Drosophila / genetics*
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Drosophila Proteins*
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Genes, Insect / genetics*
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Head / embryology
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In Situ Hybridization
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Molecular Sequence Data
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Protein Binding
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
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Sequence Homology, Amino Acid
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Tissue Distribution
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Trans-Activators / genetics*
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Trans-Activators / metabolism
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Transcription, Genetic
Substances
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CrebB protein, Drosophila
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Cyclic AMP Response Element-Binding Protein
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DNA-Binding Proteins
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Drosophila Proteins
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Repressor Proteins
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Trans-Activators
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Cyclic AMP Response Element Modulator