Abstract
A retrospective comparative study of the use of antianginal drugs in 1987 and 1992/93 has been carried out in unselected series of patients admitted for angiographic evaluation. Compared with the patients in 1987 the patients in 1992/93 were treated with approximately 50% of the doses of beta-blockers and isosorbide dinitrate. There was also a considerable reduction of the proportion of patients who received doses of beta-blockers of a similar level as used in large multicentre studies showing improved survival after myocardial infarction. The explanation of this change in therapy may be due, at least partly, to a general fear of side-effects.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adrenergic beta-Antagonists / administration & dosage*
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Adrenergic beta-Antagonists / adverse effects
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Adult
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Aged
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Angina Pectoris / drug therapy*
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Angina, Unstable / drug therapy*
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Female
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Humans
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Isosorbide Dinitrate / administration & dosage*
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Isosorbide Dinitrate / adverse effects
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Male
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Metoprolol / administration & dosage
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Metoprolol / adverse effects
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Middle Aged
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Propranolol / administration & dosage
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Propranolol / adverse effects
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Retrospective Studies
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Timolol / administration & dosage
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Timolol / adverse effects
Substances
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Adrenergic beta-Antagonists
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Timolol
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Propranolol
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Metoprolol
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Isosorbide Dinitrate