We found a t(11;14)(q13;q32) translocation in six patients with multiple myeloma (MM) or plasma cell leukemia. In five of them, rearrangements of BCL1 and PRAD1 could be studied. Two patients showed a rearrangement only with the Prad1 probe, located 120 kb telomeric of the major translocation cluster. The three other patients lacked rearrangements with both Bcl1 and Prad1.