Abstract
The expression of CD25 and CD45RO in lymphocytes from patients with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus antigens was analyzed by flow cytometry. It is suggested that the defects in the immune response to cytomegalovirus and varicella-zoster virus in patients with acute lymphoblastic leukemia on chemotherapy are in the expression of CD25 and in the switching of CD45RA cells to CD45RO cells.
MeSH terms
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CD4 Antigens / analysis
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Child
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Child, Preschool
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Cytomegalovirus / immunology*
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Herpesvirus 3, Human / immunology*
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Humans
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Leukocyte Common Antigens / immunology*
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Lymphocytes / chemistry
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Lymphocytes / immunology
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Lymphocytes / virology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
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Receptors, Interleukin-2 / analysis
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Receptors, Interleukin-2 / immunology*
Substances
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CD4 Antigens
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Receptors, Interleukin-2
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Leukocyte Common Antigens