Abstract
5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone (MET-CAMO) suppressed morphine-induced antinociception but had no effect on antinociception mediated by delta- or kappa-opioid receptors after a single i.c.v. 1-nmol injection from 8 to 72 h before testing. MET-CAMO had no agonist effects in the mouse tail-flick assay in doses up to 100 nmol. MET-CAMO is the first N-methylated morphine derivative which shows such long-lasting mu-selective opioid receptor antagonism with no agonistic properties.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analgesics / pharmacology
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Animals
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Hydromorphone / analogs & derivatives*
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Hydromorphone / pharmacology
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Injections, Intraventricular
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Mice
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Morphine / antagonists & inhibitors
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Morphine / pharmacology
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Pain Measurement / drug effects
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Reaction Time / drug effects
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Receptors, Opioid, mu / antagonists & inhibitors*
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Receptors, Opioid, mu / drug effects
Substances
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Analgesics
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Receptors, Opioid, mu
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5-methyl-14-(4-nitrocinnamoylamino)-7,8-dihydromorphinone
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Morphine
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Hydromorphone