Abstract
Galanin- and bethanechol-activated K+ currents have been studied in mudpuppy atrial myocytes. The galanin and bethanechol K+ currents were time-dependent and inwardly rectifying. In GTP gamma S, the galanin and bethanechol currents were reduced progressively as G-protein gated K+ channels became activated. GDP beta S inhibited agonist-induced outward currents. We conclude that galanin and bethanechol activate the same or a very similar inwardly rectifying K+ conductance and that activation of a G protein is required.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Atrial Function
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Bethanechol
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Bethanechol Compounds / pharmacology*
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Galanin
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Guanosine 5'-O-(3-Thiotriphosphate) / pharmacology*
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Guanosine Diphosphate / analogs & derivatives*
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Guanosine Diphosphate / pharmacology
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Heart Atria / cytology
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Heart Atria / drug effects
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Membrane Potentials / drug effects
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Membrane Potentials / physiology
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Necturus
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Peptides / pharmacology*
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Potassium / metabolism*
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Thionucleotides / pharmacology*
Substances
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Bethanechol Compounds
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Peptides
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Thionucleotides
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Bethanechol
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Guanosine Diphosphate
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Guanosine 5'-O-(3-Thiotriphosphate)
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guanosine 5'-O-(2-thiodiphosphate)
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Galanin
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Potassium