Abstract
Staphylococcus aureus enterotoxin B (SEB) was added to explants of fetal human intestine in organ culture or administered into the lumen of fetal small intestine prior to culture. Both routes produced a massive increase in lamina propria T cells expressing V beta 3, and to a lesser extent, those expressing V beta 5 and V beta 12. SEB-activated lamina propria T cells produced interleukin-2 and interferon-gamma and T cell activation was accompanied by tissue damage, which was inhibited by FK506.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Bacterial / immunology*
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Enterotoxins / immunology*
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Humans
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Intestinal Mucosa / immunology
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Intestinal Mucosa / pathology
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Intestine, Small / immunology*
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Intestine, Small / pathology
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Lymphocyte Activation / drug effects
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Organ Culture Techniques
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Staphylococcus aureus / immunology*
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T-Lymphocytes / immunology*
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Tacrolimus / pharmacology
Substances
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Antigens, Bacterial
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Enterotoxins
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Receptors, Antigen, T-Cell, alpha-beta
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Tacrolimus