Abstract
MHC class I molecules present degradation products derived from intracellular proteins, whereas MHC class II molecules generally present peptides derived from extracellular or surface proteins. Recent insights into the cell biology of MHC class I and II molecules explain this difference.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Antigen-Presenting Cells / metabolism
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Antigens / immunology*
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Antigens / metabolism
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Biological Transport
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Endocytosis
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Endopeptidases / metabolism
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Epitopes / immunology
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Epitopes / metabolism
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Histocompatibility Antigens Class I / immunology*
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Histocompatibility Antigens Class I / metabolism
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Histocompatibility Antigens Class II / immunology*
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Histocompatibility Antigens Class II / metabolism
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Humans
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Mice
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Models, Biological
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Peptide Fragments / immunology*
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Peptide Fragments / metabolism
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Protein Binding
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beta 2-Microglobulin / metabolism
Substances
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Antigens
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Epitopes
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Peptide Fragments
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beta 2-Microglobulin
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Endopeptidases