Abstract
We have studied changes on endogenous acetylcholine (ACh) release evoked by different agents from rat neostriatal slices after quinolinic acid (QA) injections. QA lesions induced a biphasic decrease on ACh release evoked by 1 microM glutamate and 50 mM KCl. ACh release evoked by selective tachykinin agonists was only significantly decreased by 250 nmol QA. These results suggest the presence of different functional cholinergic cell populations, with tachykinin-responsive cholinergic neurons selectively spared.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / metabolism*
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Animals
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Dose-Response Relationship, Drug
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Glutamates / pharmacology*
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Glutamic Acid
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In Vitro Techniques
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Male
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Microinjections
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Neostriatum / drug effects
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Neostriatum / pathology
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Neostriatum / physiology*
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Neurokinin A / analogs & derivatives*
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Neurokinin A / pharmacology
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Neurons / drug effects
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Neurons / pathology
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Neurons / physiology*
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Peptide Fragments / pharmacology*
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Potassium Chloride / pharmacology*
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Quinolinic Acid / administration & dosage
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Quinolinic Acid / toxicity*
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Rats
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Rats, Sprague-Dawley
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Substance P / analogs & derivatives*
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Substance P / pharmacology
Substances
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Glutamates
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Peptide Fragments
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neurokinin A (4-10), Nle(10)-
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substance P, Sar(9)-Met(O2)(11)-
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Substance P
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Glutamic Acid
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Potassium Chloride
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Neurokinin A
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Quinolinic Acid
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Acetylcholine