Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma

J Am Osteopath Assoc. 1993 Apr;93(4):502-4, 507.

Abstract

Ovarian dysgerminoma is the most common ovarian malignancy in young women. Conservative treatment is indicated in the reproductive-age woman who wishes to preserve childbearing capacity. This case report describes a patient with ovarian dysgerminoma who underwent chemotherapy with a cisplatin-vinblastine-bleomycin regimen that resulted in serious toxic complications--including cortical blindness and seizures--that were transient in nature. Although current chemotherapy regimens have dramatically improved the overall survival of women with germ-cell tumors, there are toxic complications such as those demonstrated in this report, and toxicity must be balanced against presumed benefit.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Bleomycin / adverse effects
  • Blindness / chemically induced*
  • Cisplatin / adverse effects
  • Dysgerminoma / drug therapy*
  • Female
  • Humans
  • Ovarian Neoplasms / drug therapy*
  • Seizures / chemically induced*
  • Vinblastine / adverse effects

Substances

  • Bleomycin
  • Vinblastine
  • Cisplatin