Abstract
Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.
MeSH terms
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Animals
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Antibodies, Viral / immunology
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Antigens, Viral / immunology*
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B-Lymphocytes / immunology
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CD4 Antigens / immunology
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CD8 Antigens / immunology
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Capsid / immunology
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Epitopes / immunology*
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H-2 Antigens
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Membrane Glycoproteins*
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Mice
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Mice, Inbred Strains
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T-Lymphocyte Subsets / immunology
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T-Lymphocytes / immunology*
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T-Lymphocytes, Cytotoxic / immunology
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T-Lymphocytes, Helper-Inducer / immunology
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Vesicular stomatitis Indiana virus / immunology*
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Viral Core Proteins / immunology
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Viral Envelope Proteins / immunology
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Virus Diseases / immunology*
Substances
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Antibodies, Viral
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Antigens, Viral
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CD4 Antigens
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CD8 Antigens
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Epitopes
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G protein, vesicular stomatitis virus
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H-2 Antigens
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Membrane Glycoproteins
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Viral Core Proteins
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Viral Envelope Proteins