Abstract
Cytokine-dependent AML cell proliferation was investigated in 16 patients. Dipyridamole and R-verapamil caused a dose-dependent inhibition of AML cell proliferation, and for both drugs the degree of inhibition was similar when testing various haematopoietic growth factors or growth factor combinations (IL3, G-CSF, GM-CSF, G-CSF + GM-CSF, TNF-alpha + GM-CSF). TNF-alpha alone increased AML cell proliferation for five patients, whereas four patients showed unaltered or decreased proliferation. Independent of this TNF-alpha effect, R-verapamil inhibited proliferation for all AML patients in the presence of TNF-alpha, whereas dipyridamole caused only a weak inhibition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Blast Crisis / pathology*
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Cell Division / drug effects*
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Cell Division / radiation effects
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Dipyridamole / pharmacology*
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Dose-Response Relationship, Drug
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Female
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Granulocyte Colony-Stimulating Factor / pharmacology
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Growth Substances / pharmacology*
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Hematopoietic Cell Growth Factors / pharmacology*
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Humans
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Interleukin-3 / pharmacology
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Kinetics
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Leukemia, Myeloid, Acute / pathology*
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Male
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Middle Aged
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Recombinant Proteins / pharmacology
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha / pharmacology
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Verapamil / pharmacology*
Substances
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Growth Substances
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Hematopoietic Cell Growth Factors
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Interleukin-3
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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Granulocyte Colony-Stimulating Factor
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Dipyridamole
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Granulocyte-Macrophage Colony-Stimulating Factor
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Verapamil