Abstract
NG-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1 beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. The data suggest a different involvement of NO at hypothalamic and pituitary level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenocorticotropic Hormone / drug effects*
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Adrenocorticotropic Hormone / metabolism
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Amino Acid Oxidoreductases / antagonists & inhibitors
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Analysis of Variance
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Animals
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Arginine / analogs & derivatives
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Arginine / pharmacology
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Cells, Cultured
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Corticotropin-Releasing Hormone / drug effects*
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Corticotropin-Releasing Hormone / metabolism
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Hypothalamus / cytology
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Hypothalamus / drug effects*
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Interleukin-1 / antagonists & inhibitors
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Male
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Nitric Oxide / pharmacology*
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Nitric Oxide Synthase
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Nitroarginine
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Pituitary Gland, Anterior / cytology
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Pituitary Gland, Anterior / drug effects*
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Rats
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Rats, Wistar
Substances
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Interleukin-1
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Nitroarginine
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Nitric Oxide
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Adrenocorticotropic Hormone
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Corticotropin-Releasing Hormone
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Arginine
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases