[Local injection of peplomycin adsorbed on activated carbon particles combined with 60Co radiation against inoperable advanced esophageal cancer--two long-term survivors]

T Oyama; T Sakakibara; K Ozaki; H Tsujimoto; S Sasaki; C Sakakura; M Shimotsuma; A Hagiwara; O Kojima; T Takahashi

[Local injection of peplomycin adsorbed on activated carbon particles combined with 60Co radiation against inoperable advanced esophageal cancer--two long-term survivors]

Gan To Kagaku Ryoho. 1993 Aug;20(11):1710-2.

[Article in Japanese]

Authors

T Oyama¹, T Sakakibara, K Ozaki, H Tsujimoto, S Sasaki, C Sakakura, M Shimotsuma, A Hagiwara, O Kojima, T Takahashi

Affiliation

¹ First Dept. of Surgery, Kyoto Prefectural University of Medicine.

PMID: 7690539

Abstract

We have developed a new dosage form, PEP-CH, consisting of peplomycin adsorbed onto small activated carbon particles. Ten patients with inoperable advanced esophageal cancer were treated with endoscopic local injection of PEP-CH combined with radiation using 60Co. Two of 5 patients who completed the treatment have survived over one year (19 and 23 months) now.

Publication types

Case Reports
English Abstract

MeSH terms

Aged
Antibiotics, Antineoplastic / administration & dosage*
Bleomycin / administration & dosage*
Carbon
Cobalt Radioisotopes / therapeutic use*
Combined Modality Therapy
Delayed-Action Preparations
Esophageal Neoplasms / drug therapy
Esophageal Neoplasms / radiotherapy
Esophageal Neoplasms / therapy*
Humans
Male
Middle Aged
Peplomycin
Prognosis

Substances

Antibiotics, Antineoplastic
Cobalt Radioisotopes
Delayed-Action Preparations
Bleomycin
Peplomycin
Carbon