Composite PAGE: an alternate method for increased separation of amplified short tandem repeat alleles

Int J Legal Med. 1993;106(2):69-73. doi: 10.1007/BF01225043.

Abstract

Genetic typing of short tandem repeat (STR) loci may require electrophoretic separation techniques which, depending on the locus, can resolve alleles differing in size by only 2, 3 or 4 base pairs (bps). Many such loci can be separated by horizontal, discontinuous polyacrylamide gel electrophoresis (hd-PAGE). However, some loci present particular separation challenges. A composite (or step) gel system consisting of 2 zones, anodal and cathodal, which differ by pore size and ionic strength, has been developed to augment resolution of DNA fragments without a need for additional electrophoretic equipment. Depending on pore size, as well as ionic strength, initial migration can be increased or decreased to effect resolution. When compared with hd-PAGE, this composite gel electrophoretic system can result in enhanced resolution of PCR amplified STR alleles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Alleles*
  • DNA / genetics*
  • Electrophoresis, Polyacrylamide Gel / instrumentation*
  • Equipment Design
  • Gene Amplification / genetics*
  • Humans
  • Myelin Basic Protein / genetics
  • Repetitive Sequences, Nucleic Acid*

Substances

  • Actins
  • Myelin Basic Protein
  • DNA