Abstract
Previous studies have shown that muscarinic agonists stimulate cGMP formation in various tissues including rat brain. As in the pineal gland cGMP formation varies considerably under various experimental conditions, in the present investigation the effects of muscarinic agonists were tested. Muscarinic agonists neither stimulated pineal cGMP formation nor affected cGMP accumulation, resulting from administration of phosphodiesterase (PDE) inhibitors, norepinephrine (NE), or sodium nitroprusside (SNP). Because muscarinic agonists are known to stimulate pineal inositol phosphate (Ip) formation we suspect that muscarine-related Ip formation does not affect cGMP formation in rat pineal gland.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-3-isobutylxanthine / pharmacology
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3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors
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Animals
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Bethanechol
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Bethanechol Compounds / pharmacology*
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Calcium / pharmacology
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Carbachol / pharmacology*
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Cells, Cultured
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Cyclic GMP / metabolism*
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Dose-Response Relationship, Drug
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Kinetics
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Male
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Nitroprusside / pharmacology
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Norepinephrine / pharmacology
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Parasympathomimetics / pharmacology*
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Pineal Gland / drug effects
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Pineal Gland / metabolism*
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Rats
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Rats, Sprague-Dawley
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Theophylline / pharmacology
Substances
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Bethanechol Compounds
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Parasympathomimetics
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Bethanechol
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Nitroprusside
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Carbachol
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Theophylline
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3',5'-Cyclic-GMP Phosphodiesterases
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Cyclic GMP
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Calcium
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1-Methyl-3-isobutylxanthine
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Norepinephrine