Abstract
The antitumor antibiotic bleomycin acts as a transcriptional inducer of the neo-ble-str operon of the transposon Tn5, increasing the resistance level to streptomycin and amikacin in Tn5-containing Escherichia coli. The mechanism may involve a recA-independent induction mediated by DNA damage.
MeSH terms
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Amikacin / pharmacology*
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Bleomycin / pharmacology*
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DNA Damage
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DNA Transposable Elements
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Drug Resistance, Microbial / genetics
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Escherichia coli / drug effects
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Escherichia coli / genetics*
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Operon / drug effects
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Plasmids
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Streptomycin / pharmacology*
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Transcription, Genetic / drug effects
Substances
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DNA Transposable Elements
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Bleomycin
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Amikacin
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Streptomycin