Abstract
Insulin-like growth factor-I (IGF-I) is a single-chain polypeptide which has multiple metabolic actions and effects on the differentiation and proliferation of a wide variety of cell types. IGF-I has endocrine, paracrine and autocrine actions and is bound in the circulation to a complex system of binding proteins which alter its bioavailability and activity. Thus its physiology is complex and is altered in a number of pathological states. This review will discuss these states and the actual and proposed therapeutic applications of recombinant human IGF-I (rhIGF-I).
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adult
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Carrier Proteins / analysis
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Carrier Proteins / chemistry
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Carrier Proteins / physiology*
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Child
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Diabetes Mellitus / physiopathology*
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Diabetes Mellitus / therapy
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Dwarfism / physiopathology*
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Dwarfism / therapy
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Female
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Humans
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Insulin-Like Growth Factor Binding Proteins
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Insulin-Like Growth Factor I / chemistry
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Insulin-Like Growth Factor I / physiology*
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Insulin-Like Growth Factor I / therapeutic use
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Pregnancy
Substances
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Carrier Proteins
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Insulin-Like Growth Factor Binding Proteins
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Insulin-Like Growth Factor I