Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis

Am J Dermatopathol. 1995 Feb;17(1):18-22. doi: 10.1097/00000372-199502000-00004.

Abstract

Annular lesions with histological changes that include a sarcoidal granulomatous reaction have been observed within hydroquinone-induced ochronotic changes in some patients. The clinical and histological similarity of these lesions to actinic granuloma has been reported previously. We describe six patients with annular granulomatous lesions located within the ochronotic areas. Three of them had evidence of systemic sarcoidosis. A comparison of the histological features of the annular lesions of this group with those of the three patients with only cutaneous sarcoidal changes showed only insignificant quantitative differences. We conclude that annular granulomatous lesions in patients with exogenous ochronosis is a form of sarcoidosis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Collagen
  • Diagnosis, Differential
  • Elastic Tissue / pathology
  • Eosinophils / pathology
  • Facial Dermatoses / chemically induced
  • Facial Dermatoses / pathology*
  • Female
  • Giant Cells / pathology
  • Granuloma Annulare / pathology*
  • Humans
  • Hydroquinones / adverse effects
  • Hypopigmentation / pathology
  • Macrophages / pathology
  • Middle Aged
  • Necrosis
  • Ochronosis / chemically induced
  • Ochronosis / pathology*
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / pathology

Substances

  • Hydroquinones
  • Collagen
  • hydroquinone