Abstract
The fra-2 gene is related to the proto-oncogene c-fos and encodes a member of the AP-1 transcription factor gene family. We have studied the expression of fra-2 during mouse embryonic development and compared it to the pattern of expression of other fos and jun family members. By in situ hybridization and immunohistochemical analysis we have shown fra-2 expression during late organogenesis. fra-2 transcripts are detected in several differentiating epithelia, developing cartilage and central nervous system. The pattern of fra-2 expression is distinct from that observed for other fos related genes, suggesting that fra-2 has a unique role in cellular differentiation during fetal development.
MeSH terms
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Adrenal Glands / embryology
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Adrenal Glands / metabolism
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Animals
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Base Sequence
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Bone and Bones / embryology
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Bone and Bones / metabolism
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Central Nervous System / embryology
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Central Nervous System / metabolism
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DNA Primers
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DNA-Binding Proteins / genetics*
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Embryonic and Fetal Development / genetics
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Fos-Related Antigen-2
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Gene Expression Regulation, Developmental*
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Genes, jun
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Immunohistochemistry
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Kidney / embryology
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Kidney / metabolism
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Mice
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Molecular Sequence Data
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Proto-Oncogene Proteins c-fos / genetics*
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Proto-Oncogene Proteins c-fos / metabolism
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Transcription Factors / genetics*
Substances
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DNA Primers
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DNA-Binding Proteins
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Fos-Related Antigen-2
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Fosl2 protein, mouse
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Proto-Oncogene Proteins c-fos
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Transcription Factors