Cystic lesions in the region of the seminal vesicles, ejaculatory ducts, or prostate are rare and can be a diagnostic and therapeutic challenge. Open surgery is often necessary for definitive treatment. Recent refinements in transrectal ultrasound imaging and endoscopic instrumentation have expanded the roles of these modalities in the management of retrovesical cysts. We present a case in which a semirigid 6.9F ureteroscope was used to access and drain a seminal vesicle cyst transurethrally, thereby obviating open surgery.