In a survey of five primary schools and one secondary school in and around the Njala University College environment, in Southern Sierra Leone, 1820 school children were examined. Ascaris lumbricoides was the most common helminth encountered (33.3%) followed by Trichuris trichiura (14.6%) and hookworm infection (10.4%). There was striking differences in the rate of infection between the various schools with the International School being the least affected by all parasites. Multiple infections were quite common, with 53.1% having one type of helminth infection, 40% had two types of helminth infections, while 6.9% had three or more helminth infections. School screening should be an important component of Primary Health Care in Sierra Leone since it offers good opportunity for disease surveillance, health education and early detection and treatment of infections before they become chronic.