Abstract
Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Cell Line
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Cytotoxins / biosynthesis
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification
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Cytotoxins / pharmacology
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Peptides*
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Spectrometry, Mass, Fast Atom Bombardment
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Streptomyces / metabolism*
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X-Ray Diffraction
Substances
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Anti-Bacterial Agents
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Cytotoxins
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Peptides