Cytogenetic analysis of Non-Hodgkin's Lymphomas (NHL) taken together with immunophenotypic and genotypic studies, may contribute to better define their morphologic classification. In this review the main cytogenetic data have been summarized, looking at a histopathologic NHL categorization that is related to a modern multiparametric approach. The correlation of non random chromosome abnormalities with NHL categories will augment information about their pathogenesis and tumor progression.