Abstract
Agonists of the dopamine D1/D5 receptors that are positively coupled to adenylyl cyclase specifically induce a slowly developing long-lasting potentiation of the field excitatory postsynaptic potential in the CA1 region of the hippocampus that lasts for > 6 hr. This potentiation is blocked by the specific D1/D5 receptor antagonist SCH 23390 and is occluded by the potentiation induced by cAMP agonists. An agonist of the D2 receptor, which is negatively coupled to adenylyl cyclase through G alpha i, did not induce potentiation. Although this slow D1/D5 agonist-induced potentiation is partially independent of N-methyl-D-aspartate receptors, it seems to share some steps with and is occluded by the late phase of long-term potentiation (LTP) produced by three repeated trains of nerve stimuli applied to the Schaffer collateral pathway. Similarly, the D1/D5 antagonist SCH 23390 attenuates the late phase of the LTP induced by repeated trains, and the D1/D5 agonist-induced potentiation is blocked by the protein synthesis inhibitor anisomycin. These results suggest that the D1/D5 receptor may be involved in the late, protein synthesis-dependent component of LTP in the hippocampal CA1 region, either as an ancillary component or as a mediator directly contributing to the late phase.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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2-Amino-5-phosphonovalerate / pharmacology
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Adenylyl Cyclases / metabolism
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Animals
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Benzazepines / pharmacology*
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Cyclic AMP / analogs & derivatives
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Cyclic AMP / pharmacology
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Cyclic AMP / physiology
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Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Evoked Potentials / drug effects
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Hippocampus / physiology*
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In Vitro Techniques
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Long-Term Potentiation / drug effects*
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Magnesium / pharmacology
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Neurons / drug effects
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Neurons / physiology*
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / physiology*
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Receptors, Dopamine D1 / agonists*
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Receptors, Dopamine D1 / antagonists & inhibitors
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Receptors, Dopamine D5
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Receptors, N-Methyl-D-Aspartate / physiology
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Thionucleotides / pharmacology
Substances
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Benzazepines
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Drd5 protein, rat
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, N-Methyl-D-Aspartate
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Thionucleotides
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Receptors, Dopamine D5
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adenosine-3',5'-cyclic phosphorothioate
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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2-Amino-5-phosphonovalerate
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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Adenylyl Cyclases
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Magnesium