Abstract
Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Autoantigens / immunology
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Autoimmunity / immunology*
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Diabetes Mellitus, Type 1 / genetics*
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Diabetes Mellitus, Type 1 / immunology*
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Haplotypes
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Humans
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Islets of Langerhans / immunology
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Major Histocompatibility Complex / genetics
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Major Histocompatibility Complex / immunology
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Mice
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Mice, Inbred NOD
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T-Lymphocytes / immunology