Structures of two classes of MHC molecules elucidated: crucial differences and similarities

P J Bjorkman; W P Burmeister

doi:10.1016/0959-440x(94)90266-6

Structures of two classes of MHC molecules elucidated: crucial differences and similarities

Curr Opin Struct Biol. 1994 Dec;4(6):852-6. doi: 10.1016/0959-440x(94)90266-6.

Authors

P J Bjorkman¹, W P Burmeister

Affiliation

¹ Division of Biology, California Institute of Technology, Pasadena, CA 91125.

PMID: 7712289
DOI: 10.1016/0959-440x(94)90266-6

Abstract

New structures of MHC molecules have significantly improved our understanding of molecular recognition in cellular immunology. Highlights include the first structure of a class II MHC molecule, complexed with a viral peptide and with a bacterial superantigen. A structure of an MHC-like Fc receptor is expected soon. Interesting comparisons can now be made between the recognition properties of MHC and MHC-like proteins.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Histocompatibility Antigens Class I / chemistry*
Histocompatibility Antigens Class I / metabolism
Histocompatibility Antigens Class II / chemistry*
Histocompatibility Antigens Class II / metabolism
Humans
Peptides / metabolism
Protein Conformation*
Receptors, Fc / chemistry
Superantigens / metabolism

Substances

Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Peptides
Receptors, Fc
Superantigens