Central nervous system involvement in systemic lupus erythematosus: a new therapeutic approach with intrathecal dexamethasone and methotrexate

G Valesini; R Priori; A Francia; G Balestrieri; A Tincani; P Airo; R Cattaneo; A Zambruni; B Troianello; M Chofflon

doi:10.1007/BF00197524

Central nervous system involvement in systemic lupus erythematosus: a new therapeutic approach with intrathecal dexamethasone and methotrexate

Springer Semin Immunopathol. 1994;16(2-3):313-21. doi: 10.1007/BF00197524.

Authors

G Valesini¹, R Priori, A Francia, G Balestrieri, A Tincani, P Airo, R Cattaneo, A Zambruni, B Troianello, M Chofflon, et al.

Affiliation

¹ Università La Sapienza, Rome, Italy.

PMID: 7716711
DOI: 10.1007/BF00197524

Abstract

In systemic lupus erythematosus (SLE), neurological involvement has been reported to occur with frequencies ranging from 14% (severe cases) to 83% (mild forms included). In spite of early diagnosis and aggressive treatment, neuropsychiatric SLE may represent a serious problem of management. We describe three cases, one with acute transverse myelitis, one with hemiparesis, and one with signs of focal and diffuse cerebral dysfunction, in whom improvement following intrathecal therapy with methotrexate and dexamethasone was observed.

Publication types

Case Reports

MeSH terms

Adolescent
Adult
Central Nervous System Diseases / complications
Central Nervous System Diseases / drug therapy*
Central Nervous System Diseases / physiopathology*
Dexamethasone / administration & dosage*
Dexamethasone / therapeutic use
Drug Combinations
Female
Humans
Injections, Spinal
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / drug therapy*
Lupus Erythematosus, Systemic / physiopathology*
Methotrexate / administration & dosage*
Methotrexate / therapeutic use
Middle Aged

Substances

Drug Combinations
Dexamethasone
Methotrexate