Abstract
In the present study the HLA-DRB and DPB1 alleles as well as CD4 and CD3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB1 0101 allele with schizophrenia (relative risk [RR] = 0.27). Furthermore a significant positive and negative association could be noticed for the CD4*A4 allele and CD4*A7/A8 genotype, respectively (RR 1.79 and 0.47, respectively). These findings suggest that some contribution of HLA class II and CD4 genes to an autoimmune-like pathogenesis in schizophrenia might exist.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Age of Onset
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Aged
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Alleles
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Antigens, CD / genetics*
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Base Sequence
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CD3 Complex / genetics*
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CD4 Antigens / genetics*
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Child
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DNA Primers
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Female
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HLA-D Antigens / genetics*
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Reference Values
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Schizophrenia / genetics*
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Schizophrenia / immunology
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Sex Factors
Substances
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Antigens, CD
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CD3 Complex
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CD4 Antigens
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DNA Primers
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HLA-D Antigens
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HLA-DR Antigens
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HLA-DRB1 Chains