Activity of praziquantel (0.5 mg kg-1) against Anoplocephala perfoliata (Cestoda) in equids

E T Lyons; S C Tolliver; S Stamper; J H Drudge; D E Granstrom; S S Collins

doi:10.1016/0304-4017(94)00661-u

Activity of praziquantel (0.5 mg kg-1) against Anoplocephala perfoliata (Cestoda) in equids

Vet Parasitol. 1995 Jan;56(1-3):255-7. doi: 10.1016/0304-4017(94)00661-u.

Authors

E T Lyons¹, S C Tolliver, S Stamper, J H Drudge, D E Granstrom, S S Collins

Affiliation

¹ Department of Veterinary Science, University of Kentucky, Lexington 40546-0099, USA.

PMID: 7732649
DOI: 10.1016/0304-4017(94)00661-u

Abstract

Praziquantel injectable formulation was administered at 0.5 mg k-1 per os to 24 equids naturally infected with 1-183 (average 40) Anoplocephala perfoliata. Drug activity was evaluated by a modified critical test method with necropsy 24 h after treatment. There was variable efficacy of 0-100% (aggregate average 85%); for 18 equids, 93-100%, for three equids, 70-85%, and for three equids, 0-20%.

MeSH terms

Administration, Oral
Animals
Cestoda / isolation & purification
Cestode Infections / drug therapy
Cestode Infections / pathology
Cestode Infections / veterinary*
Female
Horse Diseases*
Horses
Intestinal Mucosa / parasitology
Intestinal Mucosa / pathology
Male
Orchiectomy
Praziquantel / administration & dosage
Praziquantel / therapeutic use*

Substances

Praziquantel