We retrospectively studied incidence, prognosis and predictive factors of hypotonous maculopathy following trabeculectomy with adjunctive mitomycin C. The subjects were 208 cases (208 eyes) with various types of glaucoma with clear media, who were followed up for at least three months postoperatively. The follow up periods ranged from 3 to 44 months with a mean of 21.1 months. The incidence of the maculopahy was 9.1% (19/208). The postoperative intraocular pressures (IOPs) varied between 1 and 6 mmHg in the presence of maculopathy. The maculopathy disappeared in 14 eyes (74%) spontaneously or following ocular hypertensive therapy including application of trichloracetic acid and subconjunctival injection of autologous blood. The final visual acuity deteriorated two lines or more in 8 eyes (42%). A discriminant analysis showed that age, history of intraocular surgery, preoperative maximum IOP, and mean deviation are the predictive factors for maculopathy. As compared with the hypotonous eyes without maculopathy, those with maculopathy tended to be younger and to have less severe visual field changes.