Abstract
Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Base Sequence
-
Blood Pressure / drug effects
-
Blood Pressure / genetics*
-
Blood Pressure / physiology*
-
Cardiovascular Physiological Phenomena*
-
Cardiovascular System / drug effects
-
Cardiovascular System / innervation*
-
Gene Expression
-
Genes, fos / drug effects
-
Genes, fos / physiology*
-
Immunohistochemistry
-
Male
-
Medulla Oblongata / drug effects
-
Medulla Oblongata / physiology*
-
Molecular Sequence Data
-
Muscimol / pharmacology
-
Neural Pathways / drug effects
-
Neural Pathways / physiology
-
Oligonucleotides, Antisense / genetics
-
Oligonucleotides, Antisense / pharmacology
-
RNA, Messenger / antagonists & inhibitors
-
RNA, Messenger / genetics
-
Rats
-
Rats, Inbred WKY
Substances
-
Oligonucleotides, Antisense
-
RNA, Messenger
-
Muscimol