Humoral and cell-mediated immune responses in healthy children after one or two doses of varicella vaccine

B Watson; C Boardman; D Laufer; S Piercy; N Tustin; D Olaleye; A Cnaan; S E Starr

doi:10.1093/clinids/20.2.316

Humoral and cell-mediated immune responses in healthy children after one or two doses of varicella vaccine

Clin Infect Dis. 1995 Feb;20(2):316-9. doi: 10.1093/clinids/20.2.316.

Authors

B Watson¹, C Boardman, D Laufer, S Piercy, N Tustin, D Olaleye, A Cnaan, S E Starr

Affiliation

¹ Division of Allergy, Immunology, and Infectious Diseases, Joseph Stokes, Jr., Research Institute, Philadelphia, Pennsylvania, USA.

PMID: 7742436
DOI: 10.1093/clinids/20.2.316

Abstract

This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral / biosynthesis*
Chickenpox / immunology*
Chickenpox / prevention & control
Chickenpox Vaccine
Child
Child, Preschool
Female
Herpesvirus 3, Human / immunology*
Humans
Immunity, Cellular
Immunization Schedule
Infant
Lymphocyte Activation / immunology
Male
Vaccines, Attenuated / administration & dosage*
Vaccines, Attenuated / immunology
Viral Vaccines / administration & dosage*
Viral Vaccines / immunology

Substances

Antibodies, Viral
Chickenpox Vaccine
Vaccines, Attenuated
Viral Vaccines