In this paper, we presented 32 dry eyes of 16 random patients with primary Sicca Syndrome graded with rose bengal (rb), Break up time of tear film (BUT) and Schirmer 1 test (S1T). Of them, the lip biopsy and tear beta 2-M level were examined and overall studied. The results showed that the grade of dry eye was closely related with both the degree of lymphocyte infiltration of lip glands and level of tear beta 2-M, and indicated that our grading method for dry eye based on rb, BUT and S1T is depandable, and the lymphocyte infiltration of both lip and lacrymal gland may be the same qualitatively and quantitatively. so, how many lymphocytes appeared in the lip gland, how much concentration would be the tear beta 2-M Therefore judging the condition of dry eye by these 5 tests is dependable and simple too, as they need no complicated equipment.