Abstract
We studied a case in which a 2-month-old premature infant was concurrently transfused with packed erythrocytes from two different human immunodeficiency virus type 1 (HIV-1)-seropositive donors in late 1984. The two donors also each singly infected a second infant. Inspection of sequences from portions of the HIV-1 genomes in each of the two donors showed a close relationship to the strain in their respective singly exposed recipients. Inspection of sequences from the dually exposed recipient provided evidence of an individual simultaneously infected with two distinct HIV-1 strains, as well as recombination of the two strains in vivo.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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HIV Infections / transmission
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HIV Infections / virology*
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HIV-1 / classification
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HIV-1 / genetics*
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Humans
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Infant, Newborn
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Infant, Premature
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Molecular Sequence Data
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Phylogeny
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Recombination, Genetic*
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Sequence Alignment
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Species Specificity
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Transfusion Reaction*
Associated data
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GENBANK/U11124
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GENBANK/U11125
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GENBANK/U11126
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GENBANK/U11127
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GENBANK/U11128
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GENBANK/U11129
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GENBANK/U11130
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GENBANK/U11131
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GENBANK/U11132
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GENBANK/U11133
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GENBANK/U11134
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GENBANK/U11135
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GENBANK/U11136
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GENBANK/U11137
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GENBANK/U11138
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GENBANK/U11139
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GENBANK/U11140
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GENBANK/U11141
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GENBANK/U11142
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GENBANK/U11143
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GENBANK/U11144
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GENBANK/U11145
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GENBANK/U11146
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GENBANK/U11147
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GENBANK/U11148
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GENBANK/U11149
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GENBANK/U11150
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GENBANK/U11151
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GENBANK/U11152
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GENBANK/U11153