Abstract
In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry
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DNA-Binding Proteins / chemistry*
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High Mobility Group Proteins / chemistry
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Histones / chemistry*
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Integration Host Factors
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Molecular Sequence Data
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Sequence Homology, Amino Acid
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Transcription Factors / chemistry
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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High Mobility Group Proteins
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Histones
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Integration Host Factors
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Transcription Factors
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histone-like protein HU, bacteria
Associated data
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GENBANK/L35044
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GENBANK/S00015
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GENBANK/S35616
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GENBANK/S37140
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GENBANK/S37142
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GENBANK/Z33259
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SWISSPROT/L35044
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SWISSPROT/S00015
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SWISSPROT/S35616
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SWISSPROT/S37140
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SWISSPROT/S37142
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SWISSPROT/Z33259