Severe mitral regurgitation caused by immobile posterior leaflet after radiotherapy

J Am Soc Echocardiogr. 1995 Mar-Apr;8(2):207-10. doi: 10.1016/s0894-7317(05)80409-2.

Abstract

Radiotherapy may affect the heart in several ways. We describe a child who had pulmonary edema caused by severe mitral regurgitation after thoracic radiotherapy for a Ewing sarcoma. Transesophageal echocardiography demonstrated this to be caused by an immobilized posterior leaflet, and valve replacement was necessary. This is the first reported patient with rapid progression to severe valvar disease after radiotherapy and in whom this novel mechanism has been demonstrated.

Publication types

  • Case Reports

MeSH terms

  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / radiotherapy
  • Child
  • Echocardiography, Transesophageal*
  • Heart Valve Prosthesis
  • Humans
  • Male
  • Mitral Valve / diagnostic imaging
  • Mitral Valve / radiation effects
  • Mitral Valve Insufficiency / diagnostic imaging
  • Mitral Valve Insufficiency / etiology*
  • Mitral Valve Insufficiency / surgery
  • Radiation Injuries / complications*
  • Radiation Injuries / diagnostic imaging
  • Radiation Injuries / surgery
  • Ribs
  • Sarcoma, Ewing / drug therapy
  • Sarcoma, Ewing / radiotherapy
  • Time Factors