Abstract
Adhalin is deficient in two forms of human muscular dystrophy, one due to mutations in the adhalin gene and one linked to an unidentified gene on chromosome 13. Because adhalin is deficient in skeletal and cardiac muscles of BIO 14.6 hamsters, which experience both myopathy and cardiomyopathy, cDNA encoding adhalin from BIO 14.6 hamster skeletal muscle was cloned and sequenced. Adhalin mRNA was expressed at normal levels in BIO 14.6 hamster cardiac muscle, and no mutation in adhalin coding sequence was found, indicating that the inherited myopathy and cardiomyopathy of the BIO 14.6 hamster are most likely not due to mutations in the adhalin gene.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Cardiomyopathy, Hypertrophic / genetics*
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Cricetinae
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / deficiency
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Cytoskeletal Proteins / genetics*
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Cytoskeletal Proteins / metabolism
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DNA, Complementary / chemistry*
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Dystroglycans
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Male
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / deficiency
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Membrane Glycoproteins / genetics*
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Membrane Glycoproteins / metabolism
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Mesocricetus
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Molecular Sequence Data
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Muscle, Skeletal / metabolism
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Mutation
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Myocardium / metabolism
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RNA, Messenger / chemistry*
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Sarcoglycans
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Sequence Alignment
Substances
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Cytoskeletal Proteins
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DAG1 protein, human
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DNA, Complementary
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Membrane Glycoproteins
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RNA, Messenger
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Sarcoglycans
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Dystroglycans