Eleven novel mutations in the NF2 tumour suppressor gene

D Bourn; G Evans; S Mason; S Tekes; L Trueman; T Strachan

doi:10.1007/BF00223872

Eleven novel mutations in the NF2 tumour suppressor gene

Hum Genet. 1995 May;95(5):572-4. doi: 10.1007/BF00223872.

Authors

D Bourn¹, G Evans, S Mason, S Tekes, L Trueman, T Strachan

Affiliation

¹ Department of Human Genetics, University of Newcastle upon Tyne, UK.

PMID: 7759081
DOI: 10.1007/BF00223872

Abstract

Eleven novel mutations were identified in the NF2 tumour suppressor gene in a panel of British NF2 patients. Screening was performed using a combination of heteroduplex and single-strand conformation polymorphism analysis on polymerase chain reaction amplified material.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
DNA / analysis
DNA / chemistry
Genes, Neurofibromatosis 2 / genetics*
Germ-Line Mutation*
Humans
Molecular Sequence Data
Neurofibromatosis 2 / genetics*
Nucleic Acid Heteroduplexes / analysis
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Repetitive Sequences, Nucleic Acid

Substances

Nucleic Acid Heteroduplexes
DNA