Abstract
Two women (63 and 68 years) presented with primary angiosarcomas of the skin which had developed on an area of chronic lymphoedema after radiosurgical treatment for breast cancer 4 and 13 years earlier. Immunohistochemistry tests formally eliminated epithelial metastasis and produced evidence in favour of lymphatic or capillary vascular proliferation. Endothelial affinity for anti-factor VIII and positive tests for certain markers of intermediary filaments (actin, vimentin) confirmed the vascular and conjunctive tissue origin of the tumours.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Breast Neoplasms / surgery
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Female
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Hemangiosarcoma / drug therapy
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Hemangiosarcoma / etiology*
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Hemangiosarcoma / pathology
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Hemangiosarcoma / surgery
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Humans
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Immunohistochemistry
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Lymph Node Excision / adverse effects
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Lymphedema / etiology*
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Mastectomy, Radical / adverse effects*
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Middle Aged
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Postoperative Complications
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Skin Neoplasms / drug therapy
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Skin Neoplasms / etiology*
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Skin Neoplasms / pathology
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Skin Neoplasms / surgery
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Syndrome