Abstract
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Cytotoxicity, Immunologic
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Fibroblasts / immunology*
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Glycoproteins / immunology
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Histocompatibility Antigens Class I / immunology
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L Cells
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Lymphocytic Choriomeningitis / immunology
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Lymphocytic choriomeningitis virus / immunology*
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Lymphoid Tissue / immunology*
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Mice
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Mice, Inbred C57BL
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Neoplasms / immunology
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T-Lymphocytes, Cytotoxic / immunology*
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Transfection
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Tumor Cells, Cultured
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Viral Proteins / immunology*
Substances
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Glycoproteins
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Histocompatibility Antigens Class I
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Viral Proteins