Abstract
In two cases of transfusion-associated graft-versus-host disease (TA-GVHD), severe bleeding tendencies were observed besides the characteristic features of the disease. An elevation of fibrin degradation products (FDP), D-dimer, thrombin-antithrombin III complex (TAT) and plasmin-alpha 2 plasmin inhibitor complex (PIC), was revealed. These findings were compatible with disseminated intravascular coagulation (DIC). To our knowledge, the association of TA-GVHD and DIC has not been described, and it is our speculation that allogeneic immune reactions may play some pathogenic role in developing DIC in TA-GVHD. The DIC may be responsible for the rapid progression of multiple organ failure (MOF) in TA-GVHD.
MeSH terms
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Aged
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Antifibrinolytic Agents / analysis
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Antithrombin III / analysis
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Cytokines / analysis
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Disseminated Intravascular Coagulation / etiology*
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Disseminated Intravascular Coagulation / pathology
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Fibrin Fibrinogen Degradation Products / analysis
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Fibrinolysin / analysis
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Graft vs Host Disease / etiology
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Graft vs Host Disease / immunology*
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Graft vs Host Disease / pathology
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HLA Antigens / analysis
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Hemostasis
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Humans
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Male
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Middle Aged
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Peptide Hydrolases / analysis
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Transfusion Reaction*
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alpha-2-Antiplasmin*
Substances
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Antifibrinolytic Agents
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Cytokines
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Fibrin Fibrinogen Degradation Products
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HLA Antigens
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alpha-2-Antiplasmin
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antithrombin III-protease complex
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plasmin-plasmin inhibitor complex
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Antithrombin III
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Peptide Hydrolases
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Fibrinolysin