Abstract
Immunoscintigraphy by 99mTc labeled mouse CEA antibody, BW 431/26, was done for 14 patients with colorectal cancer. All patients underwent body scan 6 and 24 hours after administration of 99mTc antibody, 30 mCi/1mg. In 13 out of 14 cases (92.9%) with colorectal cancer, the specific accumulation of 99mTc was shown. The count ratio between the lesion and normal tissue indicating the accumulation of labeled antibody was calculated as 2.6 to 12.8. The hepatic metastasis could be demonstrated as cold spots in one case and as hot spots in the other case. No adverse reaction was noticed in any of patients examined. These results indicate that immunoscintigraphy by 99mTc-CEA antibody detects carcinoma of the colon excellently, and is quite useful clinically. With SPECT, it is possible to localize the site of the lesion more distinctly and to predict the accumulation of the antibody in the tumor as a treatment application.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Animals
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Antibodies, Monoclonal*
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Antibodies, Neoplasm*
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Biomarkers, Tumor / analysis*
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Biomarkers, Tumor / immunology
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Carcinoembryonic Antigen / analysis*
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Carcinoembryonic Antigen / immunology
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Carcinoma / chemistry
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Carcinoma / diagnostic imaging*
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Carcinoma / secondary
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Cecal Neoplasms / chemistry
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Cecal Neoplasms / diagnostic imaging
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Cecal Neoplasms / pathology
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Colonic Neoplasms / chemistry
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Colonic Neoplasms / diagnostic imaging*
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Colonic Neoplasms / pathology
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Female
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Humans
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / secondary
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Male
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Mice
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Middle Aged
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Neoplasm Proteins / analysis*
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Rectal Neoplasms / chemistry
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Rectal Neoplasms / diagnostic imaging
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Rectal Neoplasms / pathology
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Sigmoid Neoplasms / chemistry
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Sigmoid Neoplasms / diagnostic imaging
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Sigmoid Neoplasms / pathology
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Technetium*
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Tomography, Emission-Computed, Single-Photon
Substances
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Antibodies, Monoclonal
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Antibodies, Neoplasm
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Biomarkers, Tumor
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Carcinoembryonic Antigen
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Neoplasm Proteins
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Technetium