Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted

Farmaco. 1995 Feb;50(2):113-7.

Abstract

The synthesis of a series of 1-(alkyl- or aryl-aminocarbonylmethyl)-2-methyl- or 2-phenyl-indoles are described. All compounds were tested for antihypertensive activity on spontaneously hypertensive rats (SHR) and some of them showed a significant reduction of the arterial pressure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemical synthesis*
  • Acetamides / chemistry
  • Acetamides / pharmacology
  • Animals
  • Antihypertensive Agents / chemical synthesis*
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / pharmacology
  • Blood Pressure / drug effects
  • Drug Evaluation, Preclinical
  • Female
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Male
  • Mice
  • Rats
  • Rats, Inbred SHR
  • Structure-Activity Relationship

Substances

  • Acetamides
  • Antihypertensive Agents
  • Indoles