Abstract
The synthesis of a series of 1-(alkyl- or aryl-aminocarbonylmethyl)-2-methyl- or 2-phenyl-indoles are described. All compounds were tested for antihypertensive activity on spontaneously hypertensive rats (SHR) and some of them showed a significant reduction of the arterial pressure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / chemistry
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Acetamides / pharmacology
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Animals
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology
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Blood Pressure / drug effects
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Drug Evaluation, Preclinical
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Female
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology
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Male
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Mice
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Rats
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Rats, Inbred SHR
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Structure-Activity Relationship
Substances
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Acetamides
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Antihypertensive Agents
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Indoles