Abstract
A transferable 55-MDa plasmid which encoded resistance to both vancomycin and high concentrations of gentamicin was identified in a clinical isolate of Enterococcus faecalis. The plasmid hybridized with probes for the vanB and aac6'aph2" resistance genes. This is the first report of linkage of glycopeptide and high-level aminoglycoside resistance genes in an Enterococcus sp.
MeSH terms
-
Base Sequence
-
Conjugation, Genetic
-
DNA, Bacterial / metabolism
-
Drug Resistance, Microbial / genetics
-
Enterococcus faecalis / drug effects*
-
Enterococcus faecalis / genetics*
-
Gentamicins / pharmacology*
-
Gram-Positive Bacterial Infections / microbiology
-
Humans
-
Molecular Sequence Data
-
Nucleic Acid Hybridization
-
Plasmids / genetics*
-
Vancomycin / pharmacology*
Substances
-
DNA, Bacterial
-
Gentamicins
-
Vancomycin